| ncRNA name | hsa-miR-21-5p |
| ncRNA Category | miRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal microvascular endothelial cells (HRMECs) |
| Methods | MTT assay, wound healing assay, tube formation assay, immunofluorescence, qPCR, Western blot |
| Expression pattern | up-regulated |
| Functional description | Inhibition of miR-21-5p could suppress high glucose-induced proliferation and angiogenesis of HRMECs, and these effects may partly dependent on the regulation of PI3K/AKT and ERK pathways via its target protein maspin. |
| PubMed ID | 29658404 |
| Year | 2018 |
| Title | Inhibition of miR-21-5p suppresses high glucose-induced proliferation and angiogenesis of human retinal microvascular endothelial cells by the regulation of AKT and ERK pathways via maspin. |
| Drug-related ncRNA | NO |
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